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Es fundamental entender que no existe evidencia clnica robusta que demuestre que un horario especfico reduzca significativamente la incidencia o severidad de efectos secundarios
Furthermore, these drugs delay gastric emptying and appear to increase satiety due to direct activity on the hypothalamus and brain stem
Both medications share similar digestive side effects, especially early in treatment
For example, concurrent use with corticosteroids may amplify the potential for fluid retention or electrolyte imbalance, particularly sodium and water retention
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