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Sampey BP, Freemerman AJ, Zhang J, Kuan P-F, Galanko JA, OConnell TM, et al

Most patients find that side effects diminish substantially by week 8-12 on a stable dose

The Science of Skin Aging: Why Topicals Arent Enough By your mid-20s, your bodys natural collagen production starts to drop by about 1% each year (NIH)