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Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H 2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years

This should be applied on alternate evenings

ALA stimulates and maintains mitochondrial activity and integrity by its action as a co-enzyme and protects the organelle from the increasing free-radical (Shaygannia et al., 2018)

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