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Storage recommendations can be different according to semaglutide brand and formulation

Clinical trials have tested weekly doses ranging from 1 mg to 12 mg, with gradual titration used to improve tolerability and minimize gastrointestinal side effects

Urgent medical attention is required for severe or persistent abdominal pain (especially if radiating to the back), persistent vomiting preventing adequate fluid intake, signs of dehydration, blood in vomit, black stools, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease

Insufficient caloric deficit, too much caloric intake within the eating window, medication dose not yet optimized, metabolic adaptation, or an underlying condition affecting metabolism

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