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Methionine supplementation at very high doses may increase homocysteine levels if B12 and folate are insufficient

This paves the way for SS-31 to be used in overcoming insulin resistance by preserving transplanted islet cells in humans

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The mechanisms here are less well characterized than in musculoskeletal tissue, but the consistent finding of preserved dopaminergic tone in BPC-157-treated animals has generated interest in potential applications for neurodegenerative conditions