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The nausea, vomiting, and diarrhea commonly associated with semaglutide therapy can lead to reduced fluid intake or increased fluid loss, potentially resulting in dry mouth (xerostomia)
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It is clear that in the Fab 3F52-bound conformation of the full length GLP-1R, the N-terminal -helix of the ECD is not perpendicular to the plane of the membrane, because the Fab fragment would collide with the membrane and the TM domain (Fig
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