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This partial agonism is intrinsic to orforglipron's binding mode: as an allosteric agonist occupying a smaller binding pocket with fewer receptor contacts than peptide ligands, it stabilizes a receptor conformation that is somewhat less efficient at coupling to Gs proteins than the fully peptide-activated state
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Adems, la regeneracin del colgeno disminuye sustancialmente los efectos del fotoenvejecimiento, las lneas de expresin y las arrugas en la cara, el cuello y el escote
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