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First, sermorelin doses in adolescents with true GHD should be titrated conservatively (typically 0.2 to 0.3 mcg/kg/day) and not escalated to adult weight-based ranges (0.5 to 1.0 mcg/kg/day) without documented evidence of inadequate IGF-1 response

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3.1.1 Effect of exercise rehabilitation on cardiopulmonary function Peak oxygen uptake (VO2peak) is an independent predictor of CVD mortality (35)