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Representative tissue specimens were embedded in paraffin, sectioned at 4 m, stained with hematoxylin and eosin (H&E), and evaluated by light microscopy using an Olympus 71 digital camera and an Olympus BX51 microscope (Japan) acquiring digital images saved as uncompressed 24-bit RGB TIFF files

Ipamorelin is a Growth Hormone Secretagogue (GHS), and it works through a completely different mechanism by mimicking a hormone called ghrelin

Subsequently, images were collected with CLSM (LSM-800, ZEISS, Germany) (DAPI, ex = 405 nm, em = 460 nm, Cy5.5, ex = 673 nm, em = 692 nm)

Why this matters: The findings suggest that GLP-1-based medications may play a meaningful role in managing heart failure in people with obesity, though the smaller trial size means further research is needed to confirm these results