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Combined with automated insulin delivery, Semaglutide resulted in an average weight loss of 8.8 kg (95% CI, 10.6 to 7.0)
In this mechanistic analysis from the SUMMIT trial, we show that tirzepatide reduced circulatory volumepressure overload and systemic inflammation in patients with obesity-related HFpEF, while mitigating cardiovascularkidney end-organ injury and loss of function
The findings of this meta-analysis suggest that GLP-1 receptor agonists are not associated with an increased risk of gastrointestinal cancers and were not associated with increased gastrointestinal cancer risk and demonstrated pooled estimates below unity for colorectal and liver cancers, findings that should be interpreted as hypothesis-generating rather than confirmatory of cancer prevention (Lingvay et al., 2018
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