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Adults in the combination cagrilintide and semaglutide group had reductions in total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and high-sensitivity C-reactive protein, and an increase in HDL cholesterol
Safe self-injection involves proper technique and adherence to instructions
monitor for polycythemia
Enrolled patients were randomized in a 5:1 ratio to receive either tirzepatide or matched placebo by once-weekly (QW) subcutaneous (SC) injection in one of two cohorts: in Cohort 1 (2.510.0 mg), patients assigned to tirzepatide received 2.5 mg for the first 4 weeks, with the dose increasing by a further 2.5 mg every 4 weeks, to the maximum dose of 10.0 mg
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