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Some men report lower testosterone levels or ongoing erectile dysfunction despite successful weight loss
reinstated December 2025 (status: monitor closely) States that restrict coverage: Michigan restricted to BMI 40 (morbid obesity) with strict prior authorization criteria
We excluded patients with bariatric surgery history and required weight measurements during baseline (90 days pre-treatment), the first year post-treatment (year 1), and the second year post-treatment (year 2), yielding 34,143 semaglutide-treated and 16,034 tirzepatide-treated patients ( Figure S1 )
GLP-1Rs are expressed in a variety of discrete areas of the brain
Published clinical research has characterised the compound in controlled trials: a Phase 2 obesity trial reported dose-dependent body-weight change in the study population (Jastreboff et al., 2023), and a separate Phase 2 trial investigated the GIP/GLP-1/glucagon agonist in people with type 2 diabetes (Rosenstock et al., 2023)
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