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Many sulfonamide derivatives of metformin exerted cytotoxicity in human breast cancer cells (MCF-7 or MDA-MB-231, or both) induced particularly by methylated phenyl sulfonamides and was associated with their ability to arrest the cell cycle in the G0/G1 phase and subsequently to cause apoptosis (Torunoglu et al., 2023)

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Your clinician reviews your medical history carefully to minimize risk and ensures dosing is increased safely over time.Contact your clinician immediately if you experience severe symptoms

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