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After sifting through numerous gut hormones, the two researchers concentrated their efforts on glucagon because they knew it had multiple targets
They work through mechanisms like cytokine modulation and NF-kB pathway inhibition
The figure below summarizes that, to date, the structures of eight different small molecule agonists have been resolved, all of which are located near the extracellular ligand-binding pocket compared to the GLP-1 peptide
This article examines the current evidence on investigational GLP-1 patches, including potential wearing durations, application methods, and safety considerations, whilst highlighting the licensed injectable alternatives available through the NHS
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