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Blanket refusals of coverage remain common at national and subnational levels, which is unethical
Most patients can restart successfully, especially when beginning at a lower dose and titrating slowly
Those with a personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, or previous episodes of pancreatitis need thorough medical evaluation before starting treatment
8 Remaining Questions and Knowledge Gaps There is strong evidence that synovitis drives worse outcomes in osteoarthritis, contributing to more severe and persistent pain, heightened pain sensitization, faster structural deterioration, and an increased need for joint replacement
thus, early detection and diagnosis are crucial
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