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Participants receiving semaglutide had a larger average reduction in HbA1c levels than those receiving dapagliflozin, with a mean difference of 8.2 mmol mol 1 (95% CI, 10.0 to 6.3 mmol mol 1 ) between the randomization groups
Understanding how these medications work individually is essential before considering their combined use
GLP-1/GIP dual agonist tirzepatide in SYNERGY-NASH trial The SYNERGY-NASH phase 2 trial evaluated tirzepatide, a dual GIP/GLP-1 receptor agonist, in patients with MASH and F2/F3 fibrosis
It also supports the activity of T-helper cells, which coordinate the broader immune response
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