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Nature 598:151158
Unlike drugs that target just one hormone, tirzepatide acts on both GLP-1 and GIP receptors, leading to greater reductions in body weight
To reduce potential interference from highmolecular-weight contaminants, including laboratory-derived PEG, the extraction protocol used only methanol, ultrapure water, and defined internal standards, without any PEG-containing reagents, and the 5-kDa ultrafiltration step largely removed macromolecules such as typical laboratory PEG polymers in the kDa range
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