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These drugs mimic the binding of the naturally produced GLP-1 hormone to its cognate receptor after food intake, which has the effect of regulating glucose homeostasis, lipid metabolism, gastric emptying and feelings of satiety 19 (Figure 1)
Cagrilintide has been characterized in peer-reviewed research and clinical investigation as a potent, selective amylin receptor agonist with an extended pharmacokinetic profile suitable for once-weekly dosing paradigms
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