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Its tertiary amine structure facilitates penetration across the bloodbrain barrier, enabling central nervous system (CNS) effects via interaction with central muscarinic receptors

Details concerning biological measurements, PCZ infusion, evaluation of DPP3 activity, analysis of pro-inflammatory cytokines, catecholamine measurements, liquid chromatographytandem mass spectrometry analysis of the RAS, isotopic renal and ileal perfusion assessment, and protein expression levels of receptors in vascular samples are provided in the supplement (Tables S1, S2)

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As of 2025 this doesnt appear to be happening

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