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L-Carnitine is an amino acid-like compound that plays a critical role in energy metabolism
In addition, polymeric nanovesicles Gem/Sul-NP which simultaneously encapsulate and deliver gemcitabine and the prolyl isomerase Pin1 inhibitor sulfopin, can effectively remodel the immunosuppressive TME and significantly increases the infiltration of CD8 IFN T cells when combined with anti-PD-1 therapy (190)
Furthermore, carnitine acetyltransferase (CAT) catalyzes the synthesis of short-chain acyl-carnitines from Acyl-CoA, which is located on the inner mitochondrial membrane, microsomes, and peroxisomes 53,54
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