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Hypertension 68 , 606613 (2016)

Impaired methylation can have significant consequences for health, including mood disorders, cognitive dysfunction, and cancer

We discuss the multi-agonists currently in clinical trials and how each new generation of these drugs improves their effectiveness

RNAi-mediated inhibition of glutathione synthesis impaired survival of multiple colon cancer cell lines, and pharmacological targeting of this metabolic pathway reduced colonization in a primary patient-derived xenograft model