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185 mTORC1 signaling promotes the Warburg effect by upregulating and activating key glycolytic enzymes, including PKM2, HK2, and lactate dehydrogenase A (LDHA)
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Upon microwave irradiation, these nanoparticles induce tumor cell death through hyperthermia and microwave dynamic effects, while the SIRP on the nanoparticle surface actively binds CD47 on tumor cells, disrupting the dont eat me signal and restoring macrophage phagocytosis
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