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In: Understanding Insulin Resistance
Epac is a cAMP-regulated guanine nucleotide exchange factor (GEF) and regulates many physiological functions via activation of monomeric G protein Rap1 (De Rooij et al., in vivo or expressing Rap1GAP that down regulates Rap1 activity in vitro attenuates the effect of 8-pCPT-2- O -Me-cAMP on Ca 2+ release and insulin release (Dzhura et al., Recent studies have demonstrated the expression of TGR5 in various cell types of the gastrointestinal tract (Lavoie et al., 2012)
Kunze T, Heps S
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Langsjoen PH, Langsjoen AM
