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03 Research-only labeling Every vial is clearly identified for laboratory research and is not intended for human or veterinary consumption.

04 Direct flow against the wall Inject the BAC water slowly down the inside of the vial

Clinical implications and practical recommendations In patients with T2DM and established heart failure, SGLT2 inhibitors currently have the strongest evidence base for improving HF outcomes and should be prioritized when not contraindicated [8, 11, 45]

Note: because the trials differed in design, population and duration, the values should not be interpreted as direct comparative efficacy

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