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The hormones in the brain which control your menstrual cycle fall to low levels in times of physical or psychological stress

Taken together, these three papers span nearly two decades of endocrinology research and form the scientific basis researchers cite when designing new protocols around GHRH-analog and ghrelin-mimetic combinations

[1] [2] This effect has contributed to its notable impact on weight loss, though in the UK it is primarily licensed for diabetes management rather than obesity treatment alone (though a higher-dose formulation, Wegovy, is available specifically for weight management)

Gradually increasing the dose as recommended by your healthcare provider can help minimize these effects and may shorten the duration of fatigue

Weight loss may begin after several weeks and continues gradually