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Genetically proxied impaired GIPR signaling and risk of 6 cancers
The body tissue distribution studies show a very high concentration of LC in mature spermatozoa and luminal fluid of cauda epididymis [26]
Upon ligand binding, GLP-1R activation enhances glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and reduces appetite, collectively improving glycemic control and promoting clinically meaningful weight reduction [19]
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