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Analysis using the Broad Institute's Connectivity Map revealed GHK significantly altered the expression of 4,000+ genes with 47 DNA repair genes stimulated and 5 suppressed at a 50% change threshold.[2] Downstream effects identified in studies include: Activation of genes associated with tissue remodeling and ECM maintenance Suppression of genes linked to chronic inflammation and tissue catabolism Apparent "reset" of gene expression profiles in aged skin cells toward patterns more characteristic of younger cells[7] A 2025 IRB-approved human clinical trial (Yuvan Research, California) involving 21 women applied a stable GHK-Cu topical gel daily for 3 months and measured skin collagen density via biopsy