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Genetic variants of glucose metabolism and exposure to smoking in African American breast cancer

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The complete re-titration schedule proceeds as follows: Weeks 1-4: 0.25 mg once weekly Weeks 5-8: 0.5 mg once weekly Weeks 9-12: 1 mg once weekly Weeks 13-16: 1.7 mg once weekly Week 17 onwards: 2.4 mg once weekly (maintenance dose) Each dose increase should occur only if the current dose is well tolerated