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Sedating Antihistamines (Diphenhydramine/Doxylamine) Mechanism: Antihistamines block H1 receptors, causing drowsiness
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However, treatments with GABA, DSIP-CBBBP, and DSIP all resulted in increased struggle times compared to the model group, with CBBBP alone not showing a similar effect, indicating a differential impact on depressive-like behaviors and highlighting the potential therapeutic value of these treatments in addressing depressive symptoms associated with insomnia ( Figure 5 highlights the substantial influence of peptide treatments on the sucrose preference in mice disrupted by PCPA
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