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Goldstein AL, Hannappel E, Sosne G, Kleinman HK (2012)

Medication should not be the first course of action, and current evidence does not support its effectiveness as a sole form of treatment, nor do medical guidelines recommend such use

As with other medications in this category, actual out-of-pocket costs would depend on insurance coverage, manufacturer programs, and pharmacy pricing

These conditions or factors are referred to as contraindications

Although these animal models (such as those employing chronic intermittent ethanol exposure paradigms) provide compelling mechanistic insights, extrapolation to human populations should be approached with caution, given interspecies physiological and behavioral differences