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They aren't substitutes for one another they're tools matched to different mechanistic questions in metabolic research
We should all want a more robust anti-doping policy in trail and ultra running and we should want the incentives to be aligned with clean sport
Most practitioners recommend starting at 250-300 mcg daily to assess tolerance, then potentially increasing to 400-500 mcg if initial response is suboptimal and no side effects occur
A study in the Journal of the American Geriatrics Society showed benefits
Mechanism of Action How It Works in the Body 1
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