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Achieving sufficient and sustained drug concentrations specifically at the site of myocardial injury remains a major obstacle for systemically administered agents due to poor pharmacokinetics, rapid clearance, and lack of specific targeting to affected cells ( Significant patient heterogeneity in baseline oxidative stress levels, comorbidities, and genetic predispositions further complicates a one-size-fits-all approach, influencing individual responses to targeted therapies (Zou et al., 2024)

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Instead of large-scale clinical trials, the majority of the research is based on laboratory studies and animal models

If you have other questions about how Wegovy compares with Rybelsus or Ozempic, talk with your doctor or pharmacist