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In practice a GP or nurse may administer off-licence by giving a sub-cutaneous (under the skin, SC) injection but it is important to remember that the GP makes their own decision and takes their own accountability and reliability if they go off-licence

Step 4: Draw the Bacteriostatic Water into the Syringe Take a sterile syringe and attach a needle to it if it isn't already attached

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Safety, Side Effects and Contraindications All three options are described as generally well tolerated

By activating both GIP and GLP-1 receptors, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying