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In this review, we highlight the past and present progress in our understanding and development of treatments based on GLP-1/glucagon co-agonism
However, sustaining weight loss over the long term is challenging
Clinical outcomes associated with drugs for obesity and overweight: a systematic review and network meta-analysis of randomized controlled trials
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Results of a 68-week double-blind trial published in the New England Journal of Medicine found that obese or overweight adult trial participants who took 2.4-milligram dose of semaglutide once a week combined with exercise and a healthy diet lost an average of 14.9% body weight
