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women of childbearing potential should use effective contraception, and semaglutide should be discontinued at least 2 months before a planned pregnancy Drug interactions : Tirzepatide may reduce oral contraceptive exposure during dose escalation

Nicotinamide adenine dinucleotide phosphate (NADP) is reduced to NADPH by G6PD with the presence of its specific substrate, glucose-6-phosphate

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The drugs belong to a family of medicines known as GLP-1 analogues originally designed to control blood sugar but that also led to weight loss by making people feel full

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