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On balance, any improvements in plasma homocysteine from moderate coffee consumption (approximately 150ml per day of the filtered preparation) may be due to a synergy of the beneficial polyphenols ingested at optimal dietary levels acting on biochemical pathways that are yet to be elucidated

Jahnsen, F.L., Moloney, E.D., Hogan, T., Upham, J.W., Burke, C.M., Holt, P.G., Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge, Thorax, 56:823-826 (2001)

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In female rats with osteopenia, lipoic acid not only stopped the bone resorption but stimulated its formation [96]