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Tradeoffs: Oral semaglutide has lower bioavailability and weaker clinical evidence than injectable
Switching from 29-gauge to 31-gauge needles makes a noticeable difference in comfort
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Excessive and prolonged stimulation of the somatotropic axis could theoretically induce effects similar to acromegaly: fluid retention, arthralgia, carpal tunnel syndrome, insulin resistance, and potentially an increased risk of proliferation of certain IGF-1-sensitive tumor cells
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