Methods Study design and PLIS cohort Participants of the risk-stratified, randomized, controlled and multicenter PLIS were recruited between 1 March 2012 and 31 August 2016 to assess potential superiority of an intensified LI compared to conventional DPP-based LI in improving glucose tolerance in people with prediabetes at high risk for T2D development
The authors of this study conducted an assessment of potential sources of bias, including blinding of outcome assessment, allocation concealment, participant and staff blinding, random sequence generation, incomplete outcome data, selective reporting, and other bias
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However, off-label side effects can lead to permanent consequences, including gastroenteritis, intestinal blockages and gastroparesis
While some studies suggest potential mood benefits, others report increased anxiety or mood changes in certain individuals