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The landmark 2008 Metabolism RCT (N=116) comparing berberine 500 mg three times daily to metformin 500 mg three times daily found no statistically significant difference in HbA1c reduction after 3 months (both approximately 2.0 percentage points) [13]

doi: 10.1016/j.envpol.2017.12.108 46 TagamiT.YanaiH.TeradaY.OzekiT

Additionally, when succinyl-CoA is converted to succinate by succinate thiokinase, one molecule of GTP is generated, which can be readily converted to ATP by nucleoside-diphosphate kinase (NDPK)

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