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They include infection of hBECs of the BBB, transcytosis, and also infection of transmigration-competent immune cells which may enter the brain as a Trojan horse. A transwell 3D co-culture of HBMECs with astrocytes and monocytes showed how ZIKV-infected monocytes could cross the BBB to enter brain tissue (Bramley et al., via infected monocytes (Nottet et al., 1996

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