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illustrated how the selective permeability of the blood-brain-barrier (BBB) and bloodCSF barrier, combined with the spatial distribution of glutathione-metabolizing enzymes, underlies region-specific vulnerability to oxidative injury in the CNS (9)
Eur J Pharmacol 885:173494
When taken this way, enzymes in the stomach and intestines may destroy much of the glutathione, meaning only a small portion enters circulation
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Following the latter protocol, we attained vacuum distillation of EBN, but failed to obtain a nitrone fraction that was free of trace amounts of nitroxides, which ultimately interfere with EPR spin-trapping experiments
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