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With a lot of volume loss, especially when the skin elasticity has declined, surgical options tend to be most effective, Byrne said, noting that the most popular procedures include full face and neck lifts plus lower eyelid surgery to tackle the toll of rapid weight loss.

GHRH analogues such as CJC-1295 and Tesamorelin mimic growth-hormone-releasing hormone, while Ipamorelin is a selective secretagogue that acts on the ghrelin/GH-secretagogue receptor

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Arent, professor and chair of the department of exercise science at the University of South Carolina

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