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Semaglutide injection solutions contain various excipients that can occasionally cause contact dermatitis or irritant reactions in susceptible individuals

Special Considerations for Patients With Existing Kidney Concerns Patients with mild to moderate kidney disease (Stage 23, eGFR 3090) may use tirzepatide with appropriate monitoring and healthcare provider oversight

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The retention concentrates in ankles, wrists, and face due to IGF-1 receptor activation in renal tubules increasing sodium reabsorption

However, the situation is more nuanced for those who have had past flare-ups