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When you lose weight quickly, your body releases less leptin (a hormone that signals energy availability), and your resting metabolic rate may dip temporarily

The GLP-1 agonists semaglutide and liraglutide, which seem new and therefore more risky, have been used for almost 20 years for people with type 2 diabetes and have been shown to be safe and well-tolerated, Levy says

The results were striking: Average total weight loss: up to 20.7% of body weight Around one-third of users lost 25% or more of their starting weight Data also showed that semaglutide 7.2mg was well tolerated , with a safety profile consistent with the 2.4mg dose and earlier semaglutide trials from Novo Nordisk This places Wegovy 7.2mg in the same league as Mounjaro 15mg in terms of outcomes

Manufacturer savings programs, pharmacy coupons, and price-shopping can lower the cost of oral semaglutide sometimes to as little as $25 per month

in cRPMI and 4% hematocrit)