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1 Introduction High-altitude environments are defined by hypobaric hypoxia, and rapid exposure to such conditions without adequate acclimatization can induce a cascade of physiological responses such as dyspnea and headache, which may progress into life-threatening acute high-altitude illness (AHAI)

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Inflammatory bowel syndrome Stomach ulcers Bone fractures Injured ligaments, nerves, and muscles Tendinopathies (tendon injuries) like tennis or golf elbow, trigger fingers, or Achilles tendinitis Ulcerative colitis (short bowel syndrome, anastomosis, and fistula) Perforated cecum (part of the large intestine) Post-surgery recovery Spinal cord injuries Arrhythmia (irregular heartbeat) Periodontitis (gum damage) The outcomes for rats may differ from those for humans