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The review also documented GSHs role in regenerating vitamin E following detoxification of lipid peroxyl radicals, its involvement in the glyoxalase systems detoxification of dicarbonyl stress induced by methylglyoxal and glyoxal, and its regulation of redox signalling through reversible S-glutathionylation of critical protein cysteine residues
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The gradual dose escalation protocol specifically aims to minimize these effects while building therapeutic benefit
Maini, E., et al
Clin Physiol 1995;15(5):417-423
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