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As a side note, it may be of interest that while the hunger hormone ghrelin appears to counteract (or rather override) the effects of GLP-1 on satiety, the commonly used anti-diabetic drug metformin appears to increase expression of GLP-1 receptors and enhance GLP-1 secretion and sensitivity in both rodents and humans

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Initially, they had planned to continue the study for a further year, but because of the lack of positive results, they cancelled the extension

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