3rd generation glp 1 agonist Repurposing glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative disorders Evolution of GLP‐1 Receptor Agonists

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The two peptides work through complementary mechanisms: tesamorelin stimulates anterior pituitary somatotrophs to release endogenous growth hormone (GH) through GHRH receptor activation, while ipamorelin amplifies GH pulse amplitude without stimulating prolactin or cortisol release, a selectivity advantage over earlier secretagogues like GHRP-6