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Published Phase 2 data shows discontinuation rates of 5-8% across active treatment groups comparable to semaglutide (STEP trials: ~7%) and tirzepatide (SURMOUNT trials: ~6-7%)
This changed significantly with the approval of Wegovy for heart disease in patients with obesity, as this allows Medicare to make patients eligible for the drug
In addition, the unprotected peptide is subject to degradation in the acid environment of the stomach
All such effects are observations drawn from preclinical, in-vitro, and animal investigations
Pylori infection, an overgrowth of Helicobacter pylori, a type of bacteria found in the digestive tract, have also been known to cause sulfur burps
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