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Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)
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Selection of additional agentssuch as calcium channel blockers or diureticsshould be guided by comorbid conditions, volume status, and patient-specific factors to achieve individualized and sustained blood pressure targets (145, 146)
[2] [3] NICE guidance (NG28) recommends GLP-1 receptor agonists for adults with type 2 diabetes who have inadequate glycaemic control despite optimal management with metformin and other oral agents, particularly when significant weight loss would be beneficial
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